HRID1949471

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID44721353

4-(3,5-Dimethyl-4H-1,2,4-triazol-4-yl)piperidine

C9H16N4

结构：CCCSC1=NC(=O)C(=Cc2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2)S1

HCID67240934

未命名化合物

PRODUCTS

生成物

结构：Cc1nnc(C)n1C1CCN(C2=NC(=O)C(=Cc3ccc4c(cnn4Cc4ccc(Cl)cc4C(F)(F)F)c3)S2)CC1

HCID67243211

未命名化合物

PROCEDURE

实验过程

5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[4-(3,5-dimethyl-[1,2,4]triazol-4-yl)-piperidin-1-yl]-thiazol-4-one was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazol-4-one and 4-(3,5-Dimethyl-[1,2,4]triazol-4-yl)piperidine following General Procedure B.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2b32c1cb072944e0b77c5f5af4f15b29
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08399681B2
来源说明: uspto-grants-2013_03

反应 SMILES

[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SCCC)=[N:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[CH3:33][C:34]1[N:38]([CH:39]2[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]2)[C:37]([CH3:45])=[N:36][N:35]=1>>[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:42]5[CH2:41][CH2:40][CH:39]([N:38]6[C:34]([CH3:33])=[N:35][N:36]=[C:37]6[CH3:45])[CH2:44][CH2:43]5)=[N:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:30])([F:31])[F:32])[CH:3]=1