HRID1949480

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67239809

未命名化合物

结构：O=Cc1ccc2c(cnn2Cc2ccc(C(F)(F)F)cc2C(F)(F)F)c1

HCID86654538

未命名化合物

PRODUCTS

生成物

结构：COC(=O)CCNC(=O)C1CN(C2=NC(=O)C(=Cc3ccc4c(cnn4Cc4ccc(C(F)(F)F)cc4C(F)(F)F)c3)S2)C1

HCID76756402

未命名化合物

PROCEDURE

实验过程

3-[(1-{5-[1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester was prepared from 3-{[1-(4-oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl ester and 1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde following General Procedure D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f00074fe79bd4eca95660cc2f602987c
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08399681B2
来源说明: uspto-grants-2013_03

反应 SMILES

[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][NH:6][C:7]([CH:9]1[CH2:12][N:11]([C:13]2[S:14][CH2:15][C:16](=[O:18])[N:17]=2)[CH2:10]1)=[O:8].[F:20][C:21]([F:45])([F:44])[C:22]1[CH:39]=[C:38]([C:40]([F:43])([F:42])[F:41])[CH:37]=[CH:36][C:23]=1[CH2:24][N:25]1[C:33]2[C:28](=[CH:29][C:30]([CH:34]=O)=[CH:31][CH:32]=2)[CH:27]=[N:26]1>>[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][NH:6][C:7]([CH:9]1[CH2:10][N:11]([C:13]2[S:14][C:15](=[CH:34][C:30]3[CH:29]=[C:28]4[C:33](=[CH:32][CH:31]=3)[N:25]([CH2:24][C:23]3[CH:36]=[CH:37][C:38]([C:40]([F:43])([F:42])[F:41])=[CH:39][C:22]=3[C:21]([F:45])([F:20])[F:44])[N:26]=[CH:27]4)[C:16](=[O:18])[N:17]=2)[CH2:12]1)=[O:8]