4-Aminopiperidine-4-carboxylic acid → HCID 67240521, compound

HRID 1949481Notes

Reaction equation

HRID 1949481 reaction equation
[Cl:1][C:2]1[CH:28]=[CH:27][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SCCC)=[N:19][C:18]4=[O:26])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:29]([F:32])([F:31])[F:30])[CH:3]=1.[NH2:33][C:34]1([C:40]([OH:42])=[O:41])[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1>>[NH2:33][C:34]1([C:40]([OH:42])=[O:41])[CH2:39][CH2:38][N:37]([C:20]2[S:21][C:17](=[CH:16][C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:27]=[CH:28][C:2]([Cl:1])=[CH:3][C:4]=3[C:29]([F:32])([F:31])[F:30])[N:8]=[CH:9]4)[C:18](=[O:26])[N:19]=2)[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 15143064-Aminopiperidine-4-carboxylic acidHCID 672409345-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazol-4-one

Product 1

HCID 67240521HCID 67240521, compound

Procedure

4-Amino-1-{5-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperidine-4-carboxylic acid was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-propylsulfanyl-thiazol-4-one and 4-amino-piperidine-4-carboxylic acid following General Procedure B.

Sources & evidence

ORD record
ord-2cb5a20b319e4b56b503796109c5467b
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

Loading…