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4-Piperidinecarboxylic acid → 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| 反応物 | 2-(Methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one | HCID 1482022 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid | HCID 67240640 | — |
反応手順
To a solution of 2-methylsulfanyl-thiazol-4-one (4.4 g, 30 mmol) in MeOH (60 mL) was added piperidine-4-carboxylic acid (3.9 g, 30 mmol). The mixture was stirred at room temperature for 16 hours. The resulting solid was collected by filtration, washed with fresh MeOH and dried to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08399681B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-72f7a526c84c4e3faa7d653322bc5d49 |
| 出典メモ | uspto-grants-2013_03 |