Pyrrolidine-1-sulfonic acid [1-(4-oxo-4,5-dihydro-thiazol-2-yl)-piperidine-4-carbonyl]-amide → Pyrrolidine-1-sulfonic acid (1-{5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperidine-4-carbonyl)-amide

HRID 1949501Notes

Reaction equation

HRID 1949501 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=O)=[CH:12][CH:13]=2)[CH:8]=[N:7]1.[O:27]=[C:28]1[CH2:32][S:31][C:30]([N:33]2[CH2:38][CH2:37][CH:36]([C:39]([NH:41][S:42]([N:45]3[CH2:49][CH2:48][CH2:47][CH2:46]3)(=[O:44])=[O:43])=[O:40])[CH2:35][CH2:34]2)=[N:29]1>>[F:26][C:2]([F:1])([F:25])[C:3]1[CH:20]=[C:19]([C:21]([F:22])([F:23])[F:24])[CH:18]=[CH:17][C:4]=1[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([CH:15]=[C:32]3[S:31][C:30]([N:33]4[CH2:34][CH2:35][CH:36]([C:39]([NH:41][S:42]([N:45]5[CH2:49][CH2:48][CH2:47][CH2:46]5)(=[O:44])=[O:43])=[O:40])[CH2:37][CH2:38]4)=[N:29][C:28]3=[O:27])=[CH:12][CH:13]=2)[CH:8]=[N:7]1

Participants

3

Reactant 2

HCID 67241120Pyrrolidine-1-sulfonic acid [1-(4-oxo-4,5-dihydro-thiazol-2-yl)-piperidine-4-carbonyl]-amideHCID 866545381-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

Product 1

HCID 76756302Pyrrolidine-1-sulfonic acid (1-{5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperidine-4-carbonyl)-amide

Procedure

Pyrrolidine-1-sulfonic acid (1-{5-[1-(2,4-bis-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperidine-4-carbonyl)-amide was prepared from 1-(2,4-Bis-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde and Pyrrolidine-1-sulfonic acid [1-(4-oxo-4,5-dihydro-thiazol-2-yl)-piperidine-4-carbonyl]-amide following General Procedure E.

Sources & evidence

ORD record
ord-79274bc81fc2422cbba4ae865d5bc998
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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