1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid → HCID 67240397, compound

HRID 1949508Notes

Reaction equation

HRID 1949508 reaction equation
[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=O)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.[O:24]=[C:25]1[CH2:29][S:28][C:27]([N:30]2[CH2:35][CH2:34][CH:33]([C:36]([OH:38])=[O:37])[CH2:32][CH2:31]2)=[N:26]1>>[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:29]4[S:28][C:27]([N:30]5[CH2:31][CH2:32][CH:33]([C:36]([OH:38])=[O:37])[CH2:34][CH2:35]5)=[N:26][C:25]4=[O:24])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:21])([F:23])[F:22])[CH:3]=1

Participants

3

Reactant 2

HCID 672406401-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acidHCID 86654587HCID 86654587, compound

Product 1

HCID 67240397HCID 67240397, compound

Procedure

1-{5-[1-(4-Fluoro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-piperidine-4-carboxylic acid was prepared from 1-(4-Fluoro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde and 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid following General Procedure E.

Sources & evidence

ORD record
ord-ee4458a00f9f4fe2bbebdbfde7d7f494
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

Loading…