HRID1949510

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N1CCN(C2=NC(=O)CS2)C[C@@H]1CO

HCID67239507

未命名化合物

结构：O=Cc1ccc2c(cnn2Cc2ccc(F)cc2C(F)(F)F)c1

HCID86654587

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCN(C2=NC(=O)C(=Cc3ccc4c(cnn4Cc4ccc(F)cc4C(F)(F)F)c3)S2)C[C@@H]1CO

HCID67241550

未命名化合物

PROCEDURE

实验过程

4-{5-[1-(4-Fluoro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-2-(R)-hydroxymethyl-piperazine-1-carboxylic acid tert-butyl ester was prepared from 1-(4-Fluoro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde and 2(R)-Hydroxymethyl-4-(4-oxo-4,5-dihydro-thiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester following general procedure D.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-acaf662840734a48a5a98b0ceffded54
来源数据集: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08399681B2
来源说明: uspto-grants-2013_03

反应 SMILES

[F:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=O)=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:20]([F:23])([F:22])[F:21])[CH:3]=1.[C:24]([O:28][C:29]([N:31]1[CH2:36][CH2:35][N:34]([C:37]2[S:38][CH2:39][C:40](=[O:42])[N:41]=2)[CH2:33][C@@H:32]1[CH2:43][OH:44])=[O:30])([CH3:27])([CH3:26])[CH3:25]>>[C:24]([O:28][C:29]([N:31]1[CH2:36][CH2:35][N:34]([C:37]2[S:38][C:39](=[CH:16][C:12]3[CH:11]=[C:10]4[C:15](=[CH:14][CH:13]=3)[N:7]([CH2:6][C:5]3[CH:18]=[CH:19][C:2]([F:1])=[CH:3][C:4]=3[C:20]([F:23])([F:22])[F:21])[N:8]=[CH:9]4)[C:40](=[O:42])[N:41]=2)[CH2:33][C@@H:32]1[CH2:43][OH:44])=[O:30])([CH3:27])([CH3:26])[CH3:25]