HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1949517Generated: November 1, 2026
Chlorosuccinimide → 3-Chloro-1H-indazole-5-carboxaldehyde
https://huagongshe.com/reaction/1949517
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 1H-Indazole-5-carboxaldehyde | HCID 21250644 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Chloro-1H-indazole-5-carboxaldehyde | HCID 178519376 | 54.4% |
Reaction Steps
To a solution of 1H-Indazole-5-carbaldehyde (3.2 g, 21.89 mmol) in acetonitrile (140 mL) was added N-Chlorosuccinimide (3.5 g, 26.27 mmol). After stirring for 50 hours at 65 to 70° C., the precipitate was filtered, washed with cold acetonitrile, abundantly with water and dried to afford the title compound as a white solid (2.15 g, 54%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08399681B2 |
|---|
| Source dataset | uspto-grants-2013_03 |
|---|
| ORD ID | ord-0c937c2e34a749659c4635a13763ea2a |
|---|
| Source note | uspto-grants-2013_03 |
|---|
