4-Chloro-2-(trifluoromethyl)benzyl bromide → 3-Chloro-1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

HRID 1949520Notes

Reaction equation

HRID 1949520 reaction equation
[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=[O:12])[CH:9]=2)[NH:4][N:3]=1.Br[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=1[C:22]([F:25])([F:24])[F:23]>>[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]=[O:12])[CH:9]=2)[N:4]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[C:22]([F:24])([F:23])[F:25])[N:3]=1

Participants

3

Reactant 2

HCID 34925974-Chloro-2-(trifluoromethyl)benzyl bromideHCID 1785193763-Chloro-1H-indazole-5-carboxaldehyde

Product 1

HCID 866545953-Chloro-1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde

Procedure

3-Chloro-1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde was prepared from 3-Chloro-1H-indazole-5-carbaldehyde and 1-Bromomethyl-4-chloro-2-trifluoromethyl-benzene following general procedure A.

Sources & evidence

ORD record
ord-d66025b2e0b74c9cbce921d5607a5ebf
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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