Proline, 4-fluoro-, cis- → HCID 67239864, compound

HRID 1949525Notes

Reaction equation

HRID 1949525 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20](SCC)=[N:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:28]([F:31])([F:30])[F:29])[CH:3]=1.[F:32][C@@H:33]1[CH2:37][NH:36][C@H:35]([C:38]([OH:40])=[O:39])[CH2:34]1>>[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:36]5[CH2:37][C@@H:33]([F:32])[CH2:34][C@H:35]5[C:38]([OH:40])=[O:39])=[N:19][C:18]4=[O:25])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:28]([F:30])([F:31])[F:29])[CH:3]=1

Participants

3

Reactant 2

HCID 10057550Proline, 4-fluoro-, cis-HCID 672401235-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one

Product 1

HCID 67239864HCID 67239864, compound

Procedure

1-[5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-4-(S)-fluoro-L-proline was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazol-4-one and 4-(S)-Fluoro-pyrrolidine-2-(S)-carboxylic acid following General Procedure C.

Sources & evidence

ORD record
ord-b055fabfad484ac5833a18a8d75cc134
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

Loading…