Formaldehyde → HCID 67239452, compound

HRID 1949534Notes

Reaction equation

[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:22]5[CH2:27][CH2:26][NH:25][C@@H:24]([CH2:28][OH:29])[CH2:23]5)=[N:19][C:18]4=[O:30])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:33]([F:36])([F:35])[F:34])[CH:3]=1.C=O.F[C:40](F)(F)C1C=C(C(F)(F)F)C=CC=1CN1C2C(=CC(C=C3SC(N4CCN(C)[C@@H](CO)C4)=NC3=O)=CC=2)C=N1>>[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([CH:16]=[C:17]4[S:21][C:20]([N:22]5[CH2:27][CH2:26][N:25]([CH3:40])[C@@H:24]([CH2:28][OH:29])[CH2:23]5)=[N:19][C:18]4=[O:30])=[CH:13][CH:14]=3)[CH:9]=[N:8]2)=[C:4]([C:33]([F:34])([F:35])[F:36])[CH:3]=1

Participants

Reactant 3

HCID 712Formaldehyde

HCID 67243214HCID 67243214, compound

HCID 86654600HCID 86654600, compound

Product 1

HCID 67239452HCID 67239452, compound

Procedure

5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-2-[3-(R)-(hydroxymethyl)-4-methylpiperazin-1-yl]-1,3-thiazol-4(5H)-one was prepared from 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-(3-(R)-hydroxymethyl-piperazin-1-yl)-thiazol-4-one and formaldehyde following procedure used for compound of example 195.

Sources & evidence

ORD record: ord-83c6b5e8c05043f49c175aa8fb673427
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399681B2

Reaction notes

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