Acetic Anhydride → HCID 67240291, compound

HRID 1949586Notes

Reaction equation

[NH2:1][C@H:2]1[CH2:6][N:5]([C:7]2[S:8][C:9](=[CH:13][C:14]3[CH:15]=[C:16]4[C:20](=[CH:21][CH:22]=3)[N:19]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:25]=3[C:31]([F:34])([F:33])[F:32])[N:18]=[CH:17]4)[C:10](=[O:12])[N:11]=2)[C@@H:4]([CH2:35][OH:36])[CH2:3]1.[C:37](OC(=O)C)(=[O:39])[CH3:38]>>[Cl:30][C:27]1[CH:28]=[CH:29][C:24]([CH2:23][N:19]2[C:20]3[C:16](=[CH:15][C:14]([CH:13]=[C:9]4[S:8][C:7]([N:5]5[C@@H:4]([CH2:35][OH:36])[CH2:3][C@@H:2]([NH:1][C:37](=[O:39])[CH3:38])[CH2:6]5)=[N:11][C:10]4=[O:12])=[CH:22][CH:21]=3)[CH:17]=[N:18]2)=[C:25]([C:31]([F:34])([F:33])[F:32])[CH:26]=1

Participants

Reactant 2

HCID 7918Acetic Anhydride

HCID 67240501HCID 67240501, compound

Product 1

HCID 67240291HCID 67240291, compound

Procedure

N-{(3R,5R)-1-[5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]-5-(hydroxymethyl)pyrrolidin-3-yl}acetamide was prepared from 2-[(2R,4R)-4-Amino-2-(hydroxymethyl)pyrrolidin-1-yl]-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-1,3-thiazol-4(5H)-one (example 257) and acetic anhydride.

Sources & evidence

ORD record: ord-cd8ec953cc4d4b629bdd0b2abbf258f0
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399681B2

Reaction notes

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