2-Chloropyrimidine → HCID 67407141, compound

Participants

Reaction Conditions

Reaction Steps

A solution containing 34 (370 mg, 1.07 mmol), DIPEA (163 mg, 1.26 mmol), and 2-chloropyrimidine (135 mg, 1.17 mmol) in anhydrous DMF (6 mL) was warmed to 70° C. After 16 h, the reaction mixture was cooled to ambient temperature and diluted with water and subsequently extracted with diethyl ether. The organic extract was washed successively with water and brine, dried over anhydrous Na2SO4, filtered, and concentrated. The crude product was purified by flash silica gel chromatography (1:1 hexanes/EtOAc) to afford 210 mg (46%) of 70 as a white solid. Mass spectrum, m/z [424] (M+H)+.

Provenance & Evidence