1H-Pyrazol-3-amine, 5-methyl- → HCID 44242167, compound

HRID 1949686Notes

Reaction equation

HRID 1949686 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]([CH2:28][CH2:29][OH:30])[C:12]([C:14]1[S:27][C:17]2[C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[O:20][CH2:21][CH2:22][C:16]=2[CH:15]=1)=[O:13])[C:5](O)=[O:6].[NH2:31][C:32]1[CH:36]=[C:35]([CH3:37])[NH:34][N:33]=1>>[NH2:31][C:32]1[CH:36]=[C:35]([CH3:37])[N:34]([C:5]([C:4]2[CH:8]=[CH:9][C:10]([N:11]([CH2:28][CH2:29][OH:30])[C:12]([C:14]3[S:27][C:17]4[C:18]5[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=5[O:20][CH2:21][CH2:22][C:16]=4[CH:15]=3)=[O:13])=[C:2]([Cl:1])[CH:3]=2)=[O:6])[N:33]=1

Participants

3

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 579003303-chloro-4-(N-(2-hydroxyethyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid

Product 1

HCID 44242167HCID 44242167, compoundYield 25%

Procedure

Following Example 91, 3-chloro-4-(N-(2-hydroxyethyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid and 3-amino-5-methylpyrazole were reacted to give 116. Yield 25% of theoretical. MS: (ESI+) 523.1

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-5473f2c8fcb6438e92c842205cbc9c91
Source dataset
uspto-grants-2013_03
Patent number
US08399690B2

Reaction notes

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