3,3-Dimethyl-1-butyne → 8-Bromo-2-(5-tert-butyl-[1,2,3]triazol-1-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene

Participants

Reaction Steps

Following the procedure for 414, Step 3, 2-azido-8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene was reacted with 3,3-dimethyl-1-butyne to afford the title compound as a pale yellow solid. LCMS (Method A): RT=4.95 min, [M+H]+=405 and 407. 1H NMR (CDCl3): 8.16 (1 H, dd, J=8.1, 0.9 Hz), 7.55 (1 H, s), 7.28 (2 H, m), 4.42 (2 H, t, J=5.1 Hz), 3.37 (2 H, t, J=5.1 Hz), 1.54 (9 H, s).

Provenance & Evidence