3-Methylbut-1-yne → 8-Bromo-2-(5-isopropyl-[1,2,3]triazol-1-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene

Participants

Reaction Steps

Following the procedure for 414, Step 3, 2-azido-8-bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene was reacted with 3-methyl-1-butyne to afford the title compound as a beige solid. LCMS (Method A): RT=4.88 min, [M+H]+=391 and 393. 1H NMR (CDCl3): 8.12 (1 H, d, J=8.5 Hz), 7.59 (1 H, s), 7.30-7.25 (2 H, m), 4.41 (2 H, t, J=5.0 Hz), 3.98-3.90 (1 H, m), 3.36 (2 H, t, J=5.0 Hz), 1.44 (3 H, s), 1.42 (3 H, s).

Provenance & Evidence