(S)-3-Hydroxypiperidine → HCID 57900466, compound

HRID 1949960Notes

Reaction equation

HRID 1949960 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]([CH3:28])[C:10]([C:12]1[S:24][C:23]2[C:22]3[CH:21]=[C:20]([C:25](O)=[O:26])[CH:19]=[CH:18][C:17]=3[O:16][CH2:15][C:14]=2[CH:13]=1)=[O:11].[OH:29][C@H:30]1[CH2:35][CH2:34][CH2:33][NH:32][CH2:31]1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[N:9]([CH3:28])[C:10]([C:12]1[S:24][C:23]2[C:22]3[CH:21]=[C:20]([C:25]([N:32]4[CH2:33][CH2:34][CH2:35][C@H:30]([OH:29])[CH2:31]4)=[O:26])[CH:19]=[CH:18][C:17]=3[O:16][CH2:15][C:14]=2[CH:13]=1)=[O:11]

Participants

3

Reactant 2

HCID 6950221(S)-3-HydroxypiperidineHCID 57900153HCID 57900153, compound

Product 1

HCID 57900466HCID 57900466, compound

Procedure

Following the procedure of Example 15 and General Procedure C, 2-((2,4-difluorophenyl)(methyl)carbamoyl)-4H-thieno[3,2-c]chromene-8-carboxylic acid and (S)-3-hydroxypiperidine were coupled to give 110bp. LCMS (ESI) m/z: 485.0

Workup

  1. customto give 110bp

Sources & evidence

ORD record
ord-b0d025cabe9543ebba00083ea0b1e495
Source dataset
uspto-grants-2013_03
Patent number
US08399690B2

Reaction notes

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