Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenamine, 2-chloro-N-methyl- → HCID 57900400, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenamine, 2-chloro-N-methyl- | HCID 136736 | — |
| 반응물 | 4,4-Dimethyl-4h-thieno[3,2-c]chromene-2-carbonyl chloride | HCID 57900461 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 57900400 | HCID 57900400 | 31% |
반응 단계
To a solution of 2-chloro-N-methylaniline (32.10 uL, 0.2750 mmol) in 1.2 M of Pyridine in methylene chloride (0.8333 mL) was added a pinch of DMAP, followed by the addition of 4,4-dimethyl-4H-thieno[3,2-c]chromene-2-carbonyl chloride (70.2 mg, 0.250 mmol). The reaction was stirred at room temperature under N2 with LC/MS monitor. The crude product was purified on silica to give 30 mg 141bp. Yield=31% of theoretical. MS: (ESI+)=385
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08399690B2 |
| 출처 데이터셋 | uspto-grants-2013_03 |
| ORD ID | ord-194d0590d99b4c40bad91e9d50584cef |
| 출처 메모 | uspto-grants-2013_03 |