HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzonitrile → 4-(1-Methylpiperidin-4-yloxy)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | 4-Piperidinol, 1-methyl- | HCID 66048 | — |
| Reactant | 4-(1-Methylpiperidin-4-yloxy)benzonitrile | HCID 11458595 | — |
| Product | 4-(1-Methylpiperidin-4-yloxy)benzaldehyde | HCID 23433297 | — |
Reaction Steps
Synthesized from 4-hydroxy-1-methylpiperidine and 4-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 4-(1-methylpiperidin-4-yloxy)benzonitrile (500 mg) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (350 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-d5219e7931cd4ad9a93800fb1def702b |
| Source note | uspto-grants-2013_03 |