HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzonitrile → 4-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzonitrile | HCID 14517 | — |
| Reactant | 1-Azabicyclo(2.2.2)octane-4-methanol | HCID 141311 | — |
| Reactant | 4-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzonitrile | HCID 66626900 | — |
| Product | 4-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzaldehyde | HCID 57934313 | — |
Reaction Steps
Synthesized from (1-azabicyclo[2.2.2]oct-4-yl)methanol and 4-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 4-(1-azabicyclo[2.2.2]oct-4-ylmethoxy)benzonitrile (200 mg) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (120 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-56844cfe624a4eb0a8246201ab341126 |
| Source note | uspto-grants-2013_03 |