HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine, 1-(2-chloroethyl)-, hydrochloride → [5-Methoxy-2-(6-methoxynaphthalen-2-yl)phenyl][4-(2-piperidin-1-yl-ethoxy)phenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine, 1-(2-chloroethyl)-, hydrochloride | HCID 74826 | — |
| Reactant | (4-Hydroxyphenyl)[5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone | HCID 57933864 | — |
| Product | [5-Methoxy-2-(6-methoxynaphthalen-2-yl)phenyl][4-(2-piperidin-1-yl-ethoxy)phenyl]methanone | HCID 57934040 | 83.5% |
Reaction Steps
Synthesized from (4-hydroxyphenyl)[5-methoxy-2-(6-methoxynaphthalen-2-yl)phenyl]methanone (1.3 g) and 1-(2-chloroethyl)piperidine hydrochloride (970 mg) according to an analogous synthetic method to Example 383 described below, the title compound (yellow viscous oil) (1.4 g) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-f22abd4885fb4937b6f5fcb50708e451 |
| Source note | uspto-grants-2013_03 |