2-(Tributylstannyl)-1,3-benzothiazole → HCID 136175574, compound

HRID 1950035Notes

Reaction equation

HRID 1950035 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8]C(=O)C)=[CH:4][C:3]=1[N:12]([CH2:30][CH3:31])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]2)=[C:16]([F:29])[CH:15]=1.C([Sn](CCCC)(CCCC)[C:37]1[S:38][C:39]2[CH:45]=[CH:44][CH:43]=[CH:42][C:40]=2[N:41]=1)CCC>>[S:38]1[C:39]2[CH:45]=[CH:44][CH:43]=[CH:42][C:40]=2[N:41]=[C:37]1[C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N:12]([CH2:30][CH3:31])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][N:23]2[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]2)=[C:16]([F:29])[CH:15]=1

Participants

3

Reactant 2

HCID 37623922-(Tributylstannyl)-1,3-benzothiazoleHCID 57933980HCID 57933980, compound

Product 1

HCID 136175574HCID 136175574, compoundYield 5.9%

Procedure

Synthesized from acetic acid 4-bromo-3-{ethyl[3-fluoro-4-(2-piperidin-1-ylethoxy)benzyl]amino}phenyl ester (50 mg) and 2-tributylstannylbenzothiazole (100 mg) according to an analogous synthetic method to Example 19, the title compound (3 mg) was obtained.

Sources & evidence

ORD record
ord-6b7cd574d89747a8aaceef5c476a94af
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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