4-Bromo-3-nitroanisole → HCID 23087064, compound

HRID 1950045Notes

Reaction equation

HRID 1950045 reaction equation
C1C2C(=CC=CC=2)C=CC=1B(O)O.BrC1C=CC(OC)=CC=1[N+]([O-])=O.[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]2[CH:43]=[CH:42][C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH:35]=2)=[C:30]([N+:44]([O-])=O)[CH:29]=1>>[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]2[CH:43]=[CH:42][C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH:35]=2)=[C:30]([NH2:44])[CH:29]=1

Participants

4

Reactant 3

HCID 792884-Bromo-3-nitroanisoleHCID 2734375(Naphthalen-2-yl)boronic acidHCID 23087372HCID 23087372, compound

Product 1

HCID 23087064HCID 23087064, compoundYield 68.2%

Procedure

Synthesized from 2-naphthylboronic acid and 4-bromo-3-nitroanisole according to an analogous synthetic method to Preparation Example 79, 2-(4-methoxy-2-nitrophenyl)naphthalene (2.3 g) was used according to an analogous synthetic method to Example 22 to provide the title compound (1.4 g).

Sources & evidence

ORD record
ord-f35b68a72821400991b49da3cad19251
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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