7-Methoxy-2-tetralone → 6-Methoxy-3-(4-methoxy-2-nitrophenyl)-1,2-dihydronaphthalene

HRID 1950049Notes

Reaction equation

HRID 1950049 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][C:9](=O)[CH2:10]2)=[CH:5][CH:4]=1.FC(F)(F)S(OC1CCC2C(=CC(OC)=CC=2)C=1)(=O)=O.C([Sn](CCCC)(CCCC)[C:39]1[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][C:40]=1[N+:47]([O-:49])=[O:48])CCC>>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6](=[CH:5][CH:4]=1)[CH2:7][CH2:8][C:9]([C:39]1[CH:44]=[CH:43][C:42]([O:45][CH3:46])=[CH:41][C:40]=1[N+:47]([O-:49])=[O:48])=[CH:10]2

Participants

4

Reactant 3

HCID 777857-Methoxy-2-tetraloneHCID 230874467-Methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonateHCID 23087474Tributyl(4-methoxy-2-nitrophenyl)tin

Product 1

HCID 230875356-Methoxy-3-(4-methoxy-2-nitrophenyl)-1,2-dihydronaphthalene

Procedure

Synthesized from 7-methoxy-2-tetralone according to an analogous synthetic method to Preparation Example 82 described above, 7-methoxy-3,4-dihydronaphthalen-2-yl trifluoromethanesulfonate (3.5 g) and tributyl(4-methoxy-2-nitrophenyl)tin (18 g) were used according to an analogous synthetic method to Preparation Example 77 to provide the title compound (1.9 g).

Workup

  1. customwere used according to an analogous synthetic method to Preparation Example 77

Sources & evidence

ORD record
ord-7c788111f8d34ec1b403a97b5b74d5b3
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

Loading…