HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluoro-2-nitrophenyl trifluoromethanesulfonate → 4-Fluoro-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluoro-2-nitrophenyl trifluoromethanesulfonate | HCID 23087161 | — |
| Reactant | (6-Methoxy-3,4-dihydronaphthalen-2-yl)trimethyltin | HCID 23087176 | — |
| Reactant | 3-(5-Fluoro-2-nitrophenyl)-7-methoxy-1,2-dihydronaphthalene | HCID 23087260 | — |
| Product | 4-Fluoro-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine | HCID 23087415 | 79.7% |
Reaction Steps
Synthesized from 5-fluoro-2-nitrophenyl trifluoromethanesulfonate and (6-methoxy-3,4-dihydronaphthalen-2-yl)trimethyltin according to an analogous synthetic method to Preparation Example 77, 3-(5-fluoro-2-nitrophenyl)-7-methoxy-1,2-dihydronaphthalene (396 mg) was used according to an analogous synthetic method to Example 30 to provide the title compound (286 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-4c63aa568ca54fa8b0459bfbdd00bae2 |
| Source note | uspto-grants-2013_03 |