反应详情

温度

80 °C

To a suspension of 7-methoxy-3-(4-methoxy-2-nitrophenyl)-1,2-dihydronaphthalene (600 mg), iron (430 mg) and ammonium chloride (830 mg) in methanol (15 ml) was added water (6 ml), and the solution was stirred for 6 hours at 80° C. The solution was filtered through celite pad, extracted with ethyl acetate, then sequentially washed with water and brine, and the solvent was evaporated in vacuo. The residue was purified by NH silica gel column chromatography (hexane-ethyl acetate system) to provide the title compound (356 mg).

1. filtrationThe solution was filtered through celite pad
2. extractionextracted with ethyl acetate
3. washsequentially washed with water and brine
4. customthe solvent was evaporated in vacuo
5. customThe residue was purified by NH silica gel column chromatography (hexane-ethyl acetate system)