Stannane, tributyl(2-nitrophenyl)- → 2-(2-Methoxy-8,9-dihydro-7H-benzocyclohepten-6-yl)phenylamine

HRID 1950080Notes

Reaction equation

HRID 1950080 reaction equation
FC(F)(F)S(OC1CCCC2C=C(OC)C=CC=2C=1)(=O)=O.C([Sn](CCCC)(CCCC)C1C=CC=CC=1[N+]([O-])=O)CCC.[CH3:44][O:45][C:46]1[CH:65]=[CH:64][C:49]2[CH:50]=[C:51]([C:55]3[CH:60]=[CH:59][CH:58]=[CH:57][C:56]=3[N+:61]([O-])=O)[CH2:52][CH2:53][CH2:54][C:48]=2[CH:47]=1>>[CH3:44][O:45][C:46]1[CH:65]=[CH:64][C:49]2[CH:50]=[C:51]([C:55]3[CH:60]=[CH:59][CH:58]=[CH:57][C:56]=3[NH2:61])[CH2:52][CH2:53][CH2:54][C:48]=2[CH:47]=1

Participants

4

Reactant 3

HCID 11338886Stannane, tributyl(2-nitrophenyl)-HCID 69775434HCID 69775434, compoundHCID 86605238HCID 86605238, compound

Product 1

HCID 579340452-(2-Methoxy-8,9-dihydro-7H-benzocyclohepten-6-yl)phenylamineYield 59.3%

Procedure

Synthesized from 2-methoxy-8,9-dihydro-7H-benzocyclohepten-6-yl trifluoromethanesulfonate and tributyl(2-nitrophenyl)tin according to an analogous synthetic method to Preparation Example 77, 3-methoxy-8-(2-nitrophenyl)-6,7-dihydro-5H-benzocycloheptene (830 mg) was used according to an analogous synthetic method to Example 57 to provide the title compound (442 mg).

Sources & evidence

ORD record
ord-6b0798a7f2104bdea268801c91e31a41
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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