1-Bromo-2-nitrobenzene → HCID 23087080, compound

HRID 1950091Notes

Reaction equation

HRID 1950091 reaction equation
BrC1C(C)(C)OC2C(C=1)=CC=C(OC)C=2.BrC1C=CC=CC=1[N+]([O-])=O.[CH3:26][O:27][C:28]1[CH:37]=[C:36]2[C:31]([CH:32]=[C:33]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=3[N+:46]([O-])=O)[C:34]([CH3:39])([CH3:38])[O:35]2)=[CH:30][CH:29]=1>>[CH3:26][O:27][C:28]1[CH:37]=[C:36]2[C:31]([CH2:32][CH:33]([C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][C:41]=3[NH2:46])[C:34]([CH3:39])([CH3:38])[O:35]2)=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 113411-Bromo-2-nitrobenzeneHCID 14970557HCID 14970557, compoundHCID 66625751HCID 66625751, compound

Product 1

HCID 23087080HCID 23087080, compoundYield 80.7%

Procedure

Synthesized from 3-bromo-7-methoxy-2,2-dimethyl-2H-chromene and 1-bromo-2-nitrobenzene according to an analogous synthetic method to Preparation Example 107 described below, 7-methoxy-2,2-dimethyl-3-(2-nitrophenyl)-2H-chromene (790 mg) was used according to an analogous synthetic method to Example 30 to provide the title compound (580 mg).

Sources & evidence

ORD record
ord-8d29b6b09a8d4c76bdee847f45f26fd6
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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