HCID 23087322, compound → HCID 23087171, compound

HRID 1950096Notes

Reaction equation

[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([O:11]C)=[CH:8][CH:9]=2)[N:4]([CH3:13])[C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[N:22]([CH2:25][CH3:26])[CH2:23][CH3:24].ClC1C2C(=CC(O)=CC=2)N(C)C=1C1C=CC(O)=CC=1N(CC)CC>>[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][C:7]([OH:11])=[CH:8][CH:9]=2)[N:4]([CH3:13])[C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][C:15]=1[N:22]([CH2:23][CH3:24])[CH2:25][CH3:26]

Participants

Reactant 2

HCID 23087322HCID 23087322, compound

HCID 57934543HCID 57934543, compound

Product 1

HCID 23087171HCID 23087171, compoundYield 37.9%

Procedure

Synthesized from [2-(3-chloro-6-methoxy-1-methyl-1H-indol-2-yl)-5-methoxyphenyl]diethylamine (96 mg) according to an analogous synthetic method to Example 364 described below, 3-chloro-2-(2-diethylamino-4-hydroxyphenyl)-1-methyl-1H-indol-6-ol (37 mg) and 3-chloro-2-(2-diethylamino-4-methoxyphenyl)-1-methyl-1H-indol-6-ol (35 mg) were obtained. 3-Chloro-2-(2-diethylamino-4-hydroxyphenyl)-1-methyl-1H-indol-6-ol:

Sources & evidence

ORD record: ord-6f7fcce39d80436fb94649c03fa94f27
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399520B2

Reaction notes

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