HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-(4-Bromo-2-fluorophenoxy)ethyl)piperidine → 6-{5-Fluoro-2-[3-fluoro-4-(2-piperidin-1-ylethoxy)phenylamino]phenyl}naphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-(4-Bromo-2-fluorophenoxy)ethyl)piperidine | HCID 23087072 | — |
| Reactant | 4-Fluoro-2-(6-methoxynaphthalen-2-yl)phenylamine | HCID 23087204 | — |
| Reactant | [4-Fluoro-2-(6-methoxynaphthalen-2-yl)phenyl][3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]amine | HCID 23087209 | — |
| Product | 6-{5-Fluoro-2-[3-fluoro-4-(2-piperidin-1-ylethoxy)phenylamino]phenyl}naphthalen-2-ol | HCID 57933996 | 82.6% |
Reaction Steps
Synthesized from 4-fluoro-2-(6-methoxynaphthalen-2-yl)phenylamine and 1-[2-(4-bromo-2-fluorophenoxy)ethyl]piperidine according to an analogous synthetic method to Example 116, [4-fluoro-2-(6-methoxynaphthalen-2-yl)phenyl][3-fluoro-4-(2-piperidin-1-ylethoxy)phenyl]amine (404 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (324 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-3a54b50ebfed4b07b0634e19dc712a79 |
| Source note | uspto-grants-2013_03 |