5-Methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine → 6-{2-[6-(2-Azepan-1-ylethoxy)pyridin-3-ylamino]-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
반응식
COC1C=CC(C2CCC3C(=CC=C(OC)C=3)C2)=C(N)C=1.BrC1C=CC(OCCN2CCCCCC2)=NC=1.[N:39]1([CH2:46][CH2:47][O:48][C:49]2[N:54]=[CH:53][C:52]([NH:55][C:56]3[CH:61]=[C:60]([O:62]C)[CH:59]=[CH:58][C:57]=3[CH:64]3[CH2:73][CH2:72][C:71]4[C:66](=[CH:67][CH:68]=[C:69]([O:74]C)[CH:70]=4)[CH2:65]3)=[CH:51][CH:50]=2)[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1>>[N:39]1([CH2:46][CH2:47][O:48][C:49]2[N:54]=[CH:53][C:52]([NH:55][C:56]3[CH:61]=[C:60]([OH:62])[CH:59]=[CH:58][C:57]=3[CH:64]3[CH2:73][CH2:72][C:71]4[CH:70]=[C:69]([OH:74])[CH:68]=[CH:67][C:66]=4[CH2:65]3)=[CH:51][CH:50]=2)[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41][CH2:40]1참가 물질
4
반응물 3
생성물 1
실험 절차
Synthesized from 5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenylamine and 1-[2-(5-bromopyridin-2-yloxy)ethyl]azepane according to an analogous synthetic method to Example 116, [6-(2-azepan-1-ylethoxy)pyridin-3-yl][5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (308 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (94 mg).
출처 및 근거
- ORD 기록
- ord-76b9a942ef9f4d8b9059ba8269b3aa31
- 출처 데이터셋
- uspto-grants-2013_03
- 특허 번호
- US08399520B2
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