HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid → 6-{2-[Ethyl(3-piperidin-4-ylbenzyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid | HCID 45073791 | — |
| Reactant | 6-(2-(Ethylamino)-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl pivalate | HCID 57934095 | — |
| Product | 6-{2-[Ethyl(3-piperidin-4-ylbenzyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934376 | 25.3% |
Reaction Steps
Synthesized from pivalic acid 6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (80 mg) and 4-(3-carboxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (100 mg) according to an analogous synthetic method to Example 209, the title compound (25 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-0ef1022b033a476ab1a5b833e049dcf5 |
| Source note | uspto-grants-2013_03 |