HCID 57934088, compound → HCID 57934094, compound

HRID 1950203Notes

Reaction equation

HRID 1950203 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].C(OC([N:36]1[CH2:41][CH2:40][CH:39]([O:42][C:43]2[CH:48]=[CH:47][C:46]([CH:49]=O)=[CH:45][C:44]=2[F:51])[CH2:38][CH2:37]1)=O)(C)(C)C>>[CH2:1]([N:3]([CH2:49][C:46]1[CH:47]=[CH:48][C:43]([O:42][CH:39]2[CH2:40][CH2:41][NH:36][CH2:37][CH2:38]2)=[C:44]([F:51])[CH:45]=1)[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2]

Participants

3

Reactant 2

HCID 57934088HCID 57934088, compoundHCID 57934253HCID 57934253, compound

Product 1

HCID 57934094HCID 57934094, compoundYield 19.3%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and 4-(2-fluoro-4-formylphenoxy)piperidine-1-carboxylic acid tert-butyl ester (75 mg) according to an analogous synthetic method to Example 238 and purified by LC-MS, the title compound (5.1 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-d9d147402f774ba9a135df3d07e54e36
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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