HCID 57934253, compound → HCID 66627066, compound

HRID 1950207Notes

Reaction equation

HRID 1950207 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[C@@H:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([O:22]C(=O)C(C)(C)C)[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].C(OC(=O)[NH:35][C:36]1([CH2:41][O:42][C:43]2[CH:48]=[CH:47][C:46]([CH:49]=O)=[CH:45][CH:44]=2)[CH2:40][CH2:39][CH2:38][CH2:37]1)(C)(C)C>>[NH2:35][C:36]1([CH2:41][O:42][C:43]2[CH:44]=[CH:45][C:46]([CH2:49][CH2:2][CH2:1][NH:3][C:4]3[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=3[C@@H:12]3[CH2:21][CH2:20][C:19]4[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=4[CH2:13]3)=[CH:47][CH:48]=2)[CH2:37][CH2:38][CH2:39][CH2:40]1

Participants

3

Reactant 2

HCID 57934253HCID 57934253, compoundHCID 57934423HCID 57934423, compound

Product 1

HCID 66627066HCID 66627066, compoundYield 61%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and tert-butyl[1-(4-formylphenoxymethyl)cyclopentyl]carbamate (74 mg) according to an analogous synthetic method to Example 238 and purified by LC-MS, the title compound (16 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-8bea710ff2944ca283c0242e467e4ef8
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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