5,6,7,8-Tetrahydro-2-naphthol → HCID 66626422, compound

HRID 1950208Notes

Reaction equation

HRID 1950208 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:5]=1[CH:12]1[CH2:21][CH2:20][C:19]2[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=2[CH2:13]1)[CH3:2].C1C2CCCCC=2C=CC=1O.[N:34]1([CH2:41][CH2:42][O:43][C:44]2[CH:51]=[CH:50][C:47]([CH:48]=O)=[CH:46][CH:45]=2)[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>>[N:34]1([CH2:41][CH2:42][O:43][C:44]2[CH:51]=[CH:50][C:47]([CH2:48][CH2:2][CH2:1][NH:3][C:4]3[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:5]=3[CH:12]3[CH2:21][CH2:20][C:19]4[CH:18]=[C:17]([OH:22])[CH:16]=[CH:15][C:14]=4[CH2:13]3)=[CH:46][CH:45]=2)[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1

Participants

4

Reactant 3

HCID 143055,6,7,8-Tetrahydro-2-naphtholHCID 35023344-(2-(azepan-1-yl)ethoxy)benzaldehydeHCID 23087525HCID 23087525, compound

Product 1

HCID 66626422HCID 66626422, compound

Procedure

Synthesized from 6-(2-ethylamino-5-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol according to an analogous synthetic method to Example 36, 642-ethylamino-5-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-ol (40 mg) and 4-(2-azepan-1-ylethoxy)benzaldehyde (202 mg) were used according to an analogous synthetic method to Example 38 to provide the title compound (32 mg).

Sources & evidence

ORD record
ord-7e9e840d345d4e53acece13647b92ce8
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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