HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivalic acid 6-(2-ethylamino-5-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester → 6-{2-{[4-(2-Azepan-1-ylethyl)benzyl]ethylamino}-5-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivalic acid 6-(2-ethylamino-5-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934366 | — |
| Reactant | 4-(2-Azepan-1-ylethyl)benzoic acid hydrochloride | HCID 66625504 | — |
| Product | 6-{2-{[4-(2-Azepan-1-ylethyl)benzyl]ethylamino}-5-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66627896 | 59.5% |
Reaction Steps
Synthesized from pivalic acid 6-(2-ethylamino-5-methoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (50 mg) and 4-(2-azepan-1-ylethyl)benzoic acid hydrochloride (100 mg) according to an analogous synthetic method to Example 152, the title compound (40 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-8328723d323c4773be8edd7ea89cd081 |
| Source note | uspto-grants-2013_03 |