HCID 57934423, compound → HCID 66627789, compound

HRID 1950232Notes

Reaction equation

HRID 1950232 reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=1[C@@H:14]1[CH2:23][CH2:22][C:21]2[CH:20]=[C:19]([O:24]C(=O)C(C)(C)C)[CH:18]=[CH:17][C:16]=2[CH2:15]1)[CH3:2].C(OC(=O)[NH:37][C:38]1([CH2:43][O:44][C:45]2[CH:50]=[CH:49][C:48]([CH:51]=O)=[CH:47][CH:46]=2)[CH2:42][CH2:41][CH2:40][CH2:39]1)(C)(C)C>>[NH2:37][C:38]1([CH2:43][O:44][C:45]2[CH:50]=[CH:49][C:48]([CH2:51][CH2:2][CH2:1][NH:3][C:4]3[CH:9]=[C:8]([O:10][CH3:11])[C:7]([O:12][CH3:13])=[CH:6][C:5]=3[C@@H:14]3[CH2:23][CH2:22][C:21]4[CH:20]=[C:19]([OH:24])[CH:18]=[CH:17][C:16]=4[CH2:15]3)=[CH:47][CH:46]=2)[CH2:42][CH2:41][CH2:40][CH2:39]1

Participants

3

Reactant 2

HCID 57934423HCID 57934423, compoundHCID 57934541pivalic acid (R)-6-(2-ethylamino-4,5-dimethoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester

Product 1

HCID 66627789HCID 66627789, compoundYield 93.1%

Procedure

Synthesized from pivalic acid (R)-6-(2-ethylamino-4,5-dimethoxyphenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (20 mg) and tert-butyl[1-(4-formylphenoxymethyl)cyclopentyl]carbamate (74 mg) according to an analogous synthetic method to Example 238 and purified by LC-MS, the title compound (24 mg) was obtained.

Workup

  1. custompurified by LC-MS

Sources & evidence

ORD record
ord-1915ebae8768453c9992176e88f0a400
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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