HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl ester → 6-{6-{[4-(2-Azepan-1-ylethyl)benzyl]ethylamino}benzo[1,3]dioxol-5-yl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934012 | — |
| Reactant | 4-(2-Azepan-1-ylethyl)benzoic acid hydrochloride | HCID 66625504 | — |
| Product | 6-{6-{[4-(2-Azepan-1-ylethyl)benzyl]ethylamino}benzo[1,3]dioxol-5-yl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 66627115 | 63.8% |
Reaction Steps
Synthesized from pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (40 mg) and 4-(2-azepan-1-ylethyl)benzoic acid hydrochloride (80 mg) according to an analogous synthetic method to Example 337 described below, the title compound (34 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-13f8f91ae2f644e6bb6e400c60c3bad8 |
| Source note | uspto-grants-2013_03 |