HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester → 6-{6-[Ethyl(4-piperidin-4-ylbenzyl)amino]benzo[1,3]dioxol-5-yl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester | HCID 22492859 | — |
| Reactant | Pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934012 | — |
| Product | 6-{6-[Ethyl(4-piperidin-4-ylbenzyl)amino]benzo[1,3]dioxol-5-yl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934519 | 40.8% |
Reaction Steps
Synthesized from pivalic acid 6-(6-ethylaminobenzo[1,3]dioxol-5-yl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (40 mg) and 4-(4-carboxyphenyl)piperidine-1-carboxylic acid tert-butyl ester (60 mg) according to an analogous synthetic method to Example 209, the title compound (20 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-63e58b65daae49b09a357661c1a260ae |
| Source note | uspto-grants-2013_03 |