4-(2-Piperidinoethoxy)benzoic acid hydrochloride → HCID 57934240, compound

HRID 1950243Notes

Reaction equation

HRID 1950243 reaction equation
C(NC1C=CC=CC=1C1CCC2C(=CC=C(OC)C=2)C1)C.Cl.N1(CCOC2C=CC(C(O)=O)=CC=2)CCCCC1.[CH2:41]([N:43]([C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=1[CH:66]1[CH2:75][CH2:74][C:73]2[C:68](=[CH:69][CH:70]=[C:71]([O:76]C)[CH:72]=2)[CH2:67]1)[CH2:44][C:45]1[CH:50]=[CH:49][C:48]([O:51][CH2:52][CH2:53][N:54]2[CH2:59][CH2:58][CH2:57][CH2:56][CH2:55]2)=[CH:47][CH:46]=1)[CH3:42]>>[CH2:41]([N:43]([CH2:44][C:45]1[CH:50]=[CH:49][C:48]([O:51][CH2:52][CH2:53][N:54]2[CH2:59][CH2:58][CH2:57][CH2:56][CH2:55]2)=[CH:47][CH:46]=1)[C:60]1[CH:65]=[CH:64][CH:63]=[CH:62][C:61]=1[CH:66]1[CH2:75][CH2:74][C:73]2[CH:72]=[C:71]([OH:76])[CH:70]=[CH:69][C:68]=2[CH2:67]1)[CH3:42]

Participants

4

Reactant 3

HCID 57438354-(2-Piperidinoethoxy)benzoic acid hydrochlorideHCID 23087458Ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amineHCID 23087479HCID 23087479, compound

Product 1

HCID 57934240HCID 57934240, compoundYield 80%

Procedure

Synthesized from ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine and 4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride according to an analogous synthetic method to Example 152, ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl][4-(2-piperidin-1-ylethoxy)benzyl]amine (507 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (394 mg).

Sources & evidence

ORD record
ord-e3c25e168ff64afbbe4a4a724e42881e
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

Loading…