HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1-Methylpiperidin-4-yloxy)benzaldehyde → (R)-6-{2-{Ethyl[4-(1-methylpiperidin-4-yloxy)benzyl]amino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1-Methylpiperidin-4-yloxy)benzaldehyde | HCID 23433297 | — |
| Reactant | pivalic acid (R)-6-(2-ethylaminophenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57933894 | — |
| Product | (R)-6-{2-{Ethyl[4-(1-methylpiperidin-4-yloxy)benzyl]amino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 57934464 | 59.7% |
Reaction Steps
Synthesized from pivalic acid (R)-6-(2-ethylaminophenyl)-5,6,7,8-tetrahydronaphthalen-2-yl ester (30 mg) and 4-(1-methylpiperidin-4-yloxy)benzaldehyde (94 mg) according to an analogous synthetic method to Example 264 and purified by LC-MS, the title compound (24 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-7af10e1670d643e1a7c768860358c1eb |
| Source note | uspto-grants-2013_03 |