HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-methylphenylamine → [4-(2-Azepan-1-ylethoxy)benzyl]ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-methylphenyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(6-Methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-methylphenylamine | HCID 23087375 | — |
| Reactant | [4-(2-Azepan-1-ylethoxy)benzyl][2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-methylphenyl]amine | HCID 66627118 | — |
| Reactant | 4-(2-Azepan-1-ylethoxy)benzoyl chloride hydrochloride | HCID 86605240 | — |
| Product | [4-(2-Azepan-1-ylethoxy)benzyl]ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-methylphenyl]amine | HCID 66627430 | — |
Reaction Steps
Synthesized from 2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-methylphenylamine and 4-(2-azepan-1-ylethoxy)benzoyl chloride hydrochloride according to an analogous synthetic method to Example 152, [4-(2-azepan-1-ylethoxy)benzyl][2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-methylphenyl]amine (565 mg) was used according to an analogous synthetic method to Example 36 to provide [4-(2-azepan-1-ylethoxy)benzyl]ethyl[2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)-3-methylphenyl]amine (437 mg). This compound (435 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (253 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-61f71b54263d4c6689714badb0dc79a3 |
| Source note | uspto-grants-2013_03 |