HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride → HCID 57934510, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2-Pyrrolidin-1-ylethoxy)benzoic acid hydrochloride | HCID 13174868 | — |
| Reactant | {2-[2-(tert-Butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenyl}ethylamine | HCID 66626847 | — |
| Reactant | HCID 66627421 | HCID 66627421 | — |
| Product | HCID 57934510 | HCID 57934510 | 87.1% |
Reaction Steps
Synthesized from {2-[2-(tert-butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenyl}ethylamine and 4-(2-pyrrolidin-1-ylethoxy)benzoic acid hydrochloride according to an analogous synthetic method to Example 152, {2-[2-(tert-butyldimethylsilyloxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl]-5-methoxyphenyl}ethyl[4-(2-pyrrolidin-1-ylethoxy)benzyl]amine (484 mg) was used according to an analogous synthetic method to Example 325 described below to provide the title compound (345 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-029fb32441564257a0e200008a0b047f |
| Source note | uspto-grants-2013_03 |