HCID 23087315, compound → HCID 23087173, compound

HRID 1950279Notes

Reaction equation

HRID 1950279 reaction equation
COC1C=CC(C2SC3C=CC(OC)=CC=3C=2)=C(N)C=1.Cl.[F:22][C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][C:31]=1[O:32][CH2:33][CH2:34][N:35]1[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]1)[C:26](O)=O.FC1C=[C:44](C=CC=1OCCN1CCCCC1)[CH2:45][NH:46][C:47]1[CH:52]=[C:51]([O:53][CH3:54])[CH:50]=[CH:49][C:48]=1[C:55]1[S:59][C:58]2[CH:60]=[CH:61][C:62]([O:64][CH3:65])=[CH:63][C:57]=2[CH:56]=1>>[CH2:45]([N:46]([CH2:26][C:25]1[CH:29]=[CH:30][C:31]([O:32][CH2:33][CH2:34][N:35]2[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:23]([F:22])[CH:24]=1)[C:47]1[CH:52]=[C:51]([O:53][CH3:54])[CH:50]=[CH:49][C:48]=1[C:55]1[S:59][C:58]2[CH:60]=[CH:61][C:62]([O:64][CH3:65])=[CH:63][C:57]=2[CH:56]=1)[CH3:44]

Participants

4

Reactant 3

HCID 23087315HCID 23087315, compoundHCID 23087425HCID 23087425, compoundHCID 666268273-Fluoro-4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride

Product 1

HCID 23087173HCID 23087173, compound

Procedure

Synthesized from 5-methoxy-2-(5-methoxybenzo[b]thiophen-2-yl)phenylamine and 3-fluoro-4-(2-piperidin-1-ylethoxy)benzoic acid hydrochloride according to an analogous synthetic method to Example 114, [3-fluoro-4-(2-piperidin-1-ylethoxy)benzyl][5-methoxy-2-(5-methoxybenzo[b]thiophen-2-yl)phenyl]amine (236 mg) was used according to an analogous synthetic method to Example 36 to provide ethyl[3-fluoro-4-(2-piperidin-1-ylethoxy)benzyl][5-methoxy-2-(5-methoxybenzo[b]thiophen-2-yl)phenyl]amine (202 mg). The total amount of this compound was used according to an analogous synthetic method to Example 111 to provide the title compound (136 mg).

Sources & evidence

ORD record
ord-efcb5e9deb5d445ea681e5b2cc52d6bf
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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