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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1950280Generated: October 30, 2026

1-[2-(4-Bromophenoxy)ethyl]piperidine → {5-(tert-Butyldimethylsilyloxy)-2-[1-(tert-butyldimethylsilyloxy)indan-5-yl]phenyl}[4-(2-piperidin-1-ylethoxy)phenyl]amine

https://huagongshe.com/reaction/1950280

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[2-(4-Bromophenoxy)ethyl]piperidineHCID 867195—
Reactant5-(Tert-butyldimethylsilyloxy)-2-[1-(tert-butyldimethylsilyloxy)indan-5-yl]phenylamineHCID 57934387—
Product{5-(tert-Butyldimethylsilyloxy)-2-[1-(tert-butyldimethylsilyloxy)indan-5-yl]phenyl}[4-(2-piperidin-1-ylethoxy)phenyl]amineHCID 5793378765.2%

Reaction Steps

Synthesized from 5-(tert-butyldimethylsilyloxy)-2-[1-(tert-butyldimethylsilyloxy)indan-5-yl]phenylamine (635 mg) and 1-[2-(4-bromophenoxy)ethyl]piperidine (385 mg) according to an analogous synthetic method to Example 116, the title compound (593 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08399520B2
Source datasetuspto-grants-2013_03
ORD IDord-1ae5f818bdb14387a53064ba35bced8d
Source noteuspto-grants-2013_03