HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(4-Bromophenoxy)ethyl]piperidine → 5-{4-Methoxy-2-[4-(2-piperidin-1-ylethoxy)phenylamino]phenyl}indan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(4-Bromophenoxy)ethyl]piperidine | HCID 867195 | — |
| Reactant | 2-[1-(Tert-butyldimethylsilyloxy)indan-5-yl]-5-methoxyphenylamine | HCID 57933735 | — |
| Reactant | {2-[1-(Tert-butyldimethylsilyloxy)indan-5-yl]-5-methoxyphenyl}[4-(2-piperidin-1-ylethoxy)phenyl]amine | HCID 66626359 | — |
| Product | 5-{4-Methoxy-2-[4-(2-piperidin-1-ylethoxy)phenylamino]phenyl}indan-1-ol | HCID 23087271 | 69% |
Reaction Steps
Synthesized from 2-[1-(tert-butyldimethylsilyloxy)indan-5-yl]-5-methoxyphenylamine and 1-[2-(4-bromophenoxy)ethyl]piperidine according to an analogous synthetic method to Example 116, {2-[1-(tert-butyldimethylsilyloxy)indan-5-yl]-5-methoxyphenyl}[4-(2-piperidin-1-ylethoxy)phenyl]amine (1.1 g) was used according to an analogous synthetic method to Example 325 to provide the title compound (608 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-b28301d9e46f4f098ec886dc7ab8fd50 |
| Source note | uspto-grants-2013_03 |