HCID 57933923, compound → 6-{2-{{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethylamino}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 1950289Notes

Reaction equation

HRID 1950289 reaction equation
N1(CCOC2C=CC(CCNC3C=C(OC)C=CC=3C3CCC4C(=CC=C(OC)C=4)C3)=CC=2)CCCCCC1.[N:40]1([CH2:47][CH2:48][O:49][C:50]2[CH:55]=[CH:54][C:53]([CH2:56][CH2:57][N:58]([CH2:79][CH3:80])[C:59]3[CH:64]=[C:63]([O:65]C)[CH:62]=[CH:61][C:60]=3[CH:67]3[CH2:76][CH2:75][C:74]4[C:69](=[CH:70][CH:71]=[C:72]([O:77]C)[CH:73]=4)[CH2:68]3)=[CH:52][CH:51]=2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[N:40]1([CH2:47][CH2:48][O:49][C:50]2[CH:55]=[CH:54][C:53]([CH2:56][CH2:57][N:58]([CH2:79][CH3:80])[C:59]3[CH:64]=[C:63]([OH:65])[CH:62]=[CH:61][C:60]=3[CH:67]3[CH2:76][CH2:75][C:74]4[CH:73]=[C:72]([OH:77])[CH:71]=[CH:70][C:69]=4[CH2:68]3)=[CH:52][CH:51]=2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1

Participants

3

Reactant 2

HCID 57933923HCID 57933923, compoundHCID 66625874{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine

Product 1

HCID 579341276-{2-{{2-[4-(2-Azepan-1-ylethoxy)phenyl]ethyl}ethylamino}-4-hydroxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-olYield 77%

Procedure

Synthesized from {2-[4-(2-azepan-1-ylethoxy)phenyl]ethyl}[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine according to an analogous synthetic method to Example 36, {2-[4-(2-azepan-1-ylethoxy)phenyl]ethyl}ethyl[5-methoxy-2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)phenyl]amine (130 mg) was used according to an analogous synthetic method to Example 111 to provide the title compound (95 mg).

Sources & evidence

ORD record
ord-b83f5d8bdab34003ad98129a2da25333
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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