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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1950294Generated: October 30, 2026

5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenylamine → {5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}[4-(2-piperidin-1-ylethoxy)benzyl]amine

https://huagongshe.com/reaction/1950294

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenylamineHCID 11219085—
Reactant4-(2-Piperidin-1-ylethoxy)benzoyl chloride hydrochlorideHCID 16111922—
Product{5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}[4-(2-piperidin-1-ylethoxy)benzyl]amineHCID 1134047773.2%

Reaction Steps

Synthesized from 5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenylamine (643 mg) and 4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride (989 mg) according to an analogous synthetic method to Example 152, the title compound (868 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08399520B2
Source datasetuspto-grants-2013_03
ORD IDord-b8c52b1a1fd4468ca79e7f232762a865
Source noteuspto-grants-2013_03