HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine, 1-(2-chloroethyl)-, hydrochloride → 2-{5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}-5-(2-piperidin-1-ylethoxy)-2,3-dihydro-1H-isoindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine, 1-(2-chloroethyl)-, hydrochloride | HCID 74826 | — |
| Reactant | 5-Hydroxy-2-{5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl} isoindole-1,3-dione | HCID 23087065 | — |
| Reactant | 2-{5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}-5-(2-piperidin-1-ylethoxy)isoindole-1,3-dione | HCID 23087399 | — |
| Product | 2-{5-Methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}-5-(2-piperidin-1-ylethoxy)-2,3-dihydro-1H-isoindole | HCID 57934425 | 86.3% |
Reaction Steps
Synthesized from 5-hydroxy-2-{5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}isoindole-1,3-dione and 1-(2-chloroethyl)piperidine hydrochloride according to an analogous synthetic method to Example 383 described below, 2-{5-methoxy-2-[2-(4-methoxyphenyl)ethyl]phenyl}-5-(2-piperidin-1-ylethoxy)isoindole-1,3-dione (772 mg) was used according to an analogous synthetic method to Example 337 to provide the title compound (630 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-60136d8a5f294983b4908a0cd5afe465 |
| Source note | uspto-grants-2013_03 |