HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride → 4-{2-{2-[3-Fluoro-4-(2-piperidin-1-ylethoxy)benzylamino]-4-methoxyphenyl}vinyl}phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride | HCID 23087126 | — |
| Reactant | Acetic acid 4-[2-(2-amino-4-methoxyphenyl)vinyl]phenyl ester | HCID 66627499 | — |
| Product | 4-{2-{2-[3-Fluoro-4-(2-piperidin-1-ylethoxy)benzylamino]-4-methoxyphenyl}vinyl}phenol | HCID 66625760 | 67.6% |
Reaction Steps
Synthesized from acetic acid 4-[2-(2-amino-4-methoxyphenyl)vinyl]phenyl ester (240 mg) and 3-fluoro-4-(2-piperidin-1-ylethoxy)benzoyl chloride hydrochloride (660 mg) according to an analogous synthetic method to Example 152, the title compound (273 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08399520B2 |
| Source dataset | uspto-grants-2013_03 |
| ORD ID | ord-121cbf6681814afb96a50577b969a1e8 |
| Source note | uspto-grants-2013_03 |